Why We Offer It

Advanced Genomics offers genomics and bioinformatics services to be used in various research fields.

Development of Potential Biomarkers

Potential biomarkers come in the form of genes and genetic variations in RNA. In order to characterize and validate potential biomarkers, there is requirement of sophisticated statistical treatments to interpret large data sets generated by microarrays.

Applications of Biomarkers

• Provide accurate information regarding drug performance
• Gives better drug development decisions for early clinical development
• Select lead candidates for clinical trials
• Characterize subtypes of disease for which therapeutic intervention is most appropriate
• Understand pharmacology of candidates

Personalized Medicine

Personalized medicine is to give right drug with the right dose at the right time to the patient. Promise of  personalized medicine is getting the treatment right first time and preventing illness when possible. Adoption of Personalized medicine is absolutely necessary to save lives, time and money.

Applications of Personalized Medicine:

• Determine aggressiveness of tumor
• Decide whether to perform surgery or use less invasive treatments
• Assess drug toxicity
• Stratify the patient populations
• Sort out the patients best suitable for particular drug and therapy

Pharmacogenomics

Allows us to predict drug response based on individuals genetic make up

Applications of Pharmacogenomics

Pharmacogenomics aids in the progression of safe, timely and effective medicines

Microarray: Infectious Diseases

• Differentiate various  kinds of infectious diseases
• Study host-pathogen interaction and mechanism of virulence
• Identify disease  as well as pathogen by host response signature
• View complete progression of an infectious disease state
• Study response of pathogen to host and host to pathogen
• Improve typing systems

Microarray: Microbiology

• Distinguish different strains of bacteria and identify bacteria to species level
• Characterize mutation in genes that confer drug resistance in bacteria
• Characterize genetic differences between isolates to the strain level
• Look at genetic variations across the complete genome
• Understand genetics of complex diseases and drug response
• Identify genes associated with resistance or predisposition towards disease
• Identify pathogenic agent by expression profile signatures
• Uncover virulence pathways consisting of new unknown genes
• Identifying virulence factors and toxins  to develop better vaccines
• Identify disease mechanism pathways for potential treatment
• Identify the specific strain responsible for disease and help clinicians for diagnostic purposes

Microarray: Immunology

• Identify genes and pathways involved in disease and other biological processes
• Regulate cell growth and apoptosis of cells
• Understand  the network and underlying gene regulations involved in signaling pathways including key genes for immune response, extracellular matrix, and signal transduction

Microarray: Biomedical Research

• Help in better understanding the biological mechanisms in disease
• Discover new targets and new drugs
• Develop predictors for tailoring individualized treatments
• Treat diseases according to specific genetic markers
• Select medication and dosage that is optimized for individual patients
• Properly stratify multiple diseases that superficially appear similar and considered as one disease
• Define the model to develop the right compounds
• Develop the model for drug mechanism, which helps in understanding of  the efficacy and toxicity
• Identify the right patients