What We Offer

Health care reform is a serious and most important issue in the government right now due to increasing cost of drugs and treatments, more side effects, and increasing number of adverse drug reactions. The reason is most of the diseases are not diagnosed properly or cured at an early stage. All these factors lead to advanced stage of disease that is difficult to treat.

Science Behind Genomics

In the nucleus of every human cell is present DNA organized into structures called chromosomes and carry out all life’s activities. Each DNA is made up of four nucleotides A, C, G, T (Adenine, Cytosine, Guanine, Thymine) that are arranged in a specific order (gene sequences) to form genes that encode functional proteins. Human genome is mostly same in all individuals but slight variations exists (1/10th of a percent).  These small variations known as single nucleotide polymorphisms (SNPs) vary from person to person and play major role in determining different appearances and health state. These SNPs in the genes produce proteins that work differently in persons. This can affect how we respond to different medicines. These variations are often inherited so parents pass on these variations to offspring along with other traits. Therefore, more closely related people have more similar DNA and more chances to have similar diseases. Some diseases cluster in families.

In additions to genes, other factors like diet, exercise, behavior, life style, environment exposure, also contribute to health and disease. Better understanding of all these interactions help to identify more effective ways to prevent and treat disease at early stage before signs and symptoms develop. The research at Advanced Genomics is meeting these challenges of 21st century medicine to provide effective genomic information that is tailored to individual’s genetic and environmental profile to better manage disease and improve health. The research is focused to the following understandings:

• How these variations contribute to the development of disease
• How they may influence the effectiveness of various treatments and therapies.
• Why some people get sick from certain infectious agents, environment exposures, and behaviors, while others not.
• Whether and to what extent individual will be affected by pathogen

Advanced Genomics provide best possible testing, early diagnosis and preventive strategies to all individuals for the assessment of their health. They are:

• Preventive Diagnosis: Advanced Genomics uses genetic and genomic tools like aCGH, SNPs sequencing and gene expression studies to provide signatures of human genome. Data (Clustering, Gene tree, heat map, expression profile, pathway analysis) from these signatures can be used to get information about family history together with personal Genome testing which is an important step in preventive genomic medicine.
• Prognostic Diagnosis: Assessment of health risk early before signs and symptoms develop. Knowledge of genetic risk allows more personalized understanding of genetic predisposition thus empowers individual to be proactive and change lifestyle. 
• Genetic Risk Assessment: Advanced Genomics combine information on multiple gene variants (SNPs sequencing), gene expression profile (fold change), and case control studies in the medical literature to estimate a level of risk for individuals (low, moderate, high). Advanced Genomics has set its position to assess genetic risk for:
• Alzheimer’s disease (APOE)
• Parkinson’s disease (LRRK2)
• Breast Cancer (BRCA 1, BRCA 2)
• Cancer Prevention:  At Advanced Genomics cancer can be detected at its earliest and more treatable stage with the help of gene expression. One can get following informations: 
• Early Detection of Cancer: Screen asymptomatic population
• Predictive Diagnosis: Family history and screening family members
• Differential Diagnosis: To identify various conditions of tumor: aggressive, non aggressive or benign
• Infectious Diseases: To identify the pathogen load (of bacteria, parasites, fungi). These array results are rapid, accurate, sensitive, precise, and reproducible, and successfully detect novel and known SNPs in various strains.
• Theranostic Tests: At Advanced Genomics, we use theranostic tests to identify patients likely to have adverse drug reactions to particular drug.
• Cytochrome P450 Test: At Advanced Genomics can perform metabolism test cytochrome P450 (CYP2C19, CYP2C9, CYP2D6, CYP3A5) to determine right dose. It is useful for certain antidepressant medications, proton pump inhibitors and various other medications.

NOTE:
All these tests are for information purpose only. These are only for overall assessment of health condition. By receiving this information, a person can take preventive measures, change diet, and make overall life style changes. It does not nor is it intended to provide medical advice, recommendations, diagnosis or treatment. Person should never disregard professional medical advice or delay seeking medical advice based on these tests. We provide total confidentiality and will never disclose to third party.